International Journal of Nanomedicine (Mar 2024)
Emerging Drug Delivery Vectors: Engineering of Plant-Derived Nanovesicles and Their Applications in Biomedicine
Abstract
Lu-Yao Yang,1,* Chao-Qing Li,1,2,* Yu-Lin Zhang,1,2 Meng-Wen Ma,3 Wan Cheng,3 Guo-Jun Zhang1,2 1School of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, People’s Republic of China; 2Hubei Shizhen Laboratory, Wuhan, 430065, People’s Republic of China; 3Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guo-Jun Zhang, School of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, People’s Republic of China, Email [email protected]: Extracellular vesicles can transmit intercellular information and transport biomolecules to recipient cells during various pathophysiological processes in the organism. Animal cell exosomes have been identified as potential nanodrugs delivery vehicles, yet they have some shortcomings such as high immunogenicity, high cytotoxicity, and complicated preparation procedures. In addition to exosomes, plant-derived extracellular vesicles (PDVs), which carry a variety of active substances, are another promising nano-transport vehicles emerging in recent years due to their stable physicochemical properties, wide source, and low cost. This work briefly introduces the collection and characterization of PDVs, then focuses on the application of PDVs as natural or engineered drug carriers in biomedicine, and finally discusses the development and challenges of PDVs in future applications.Keywords: plant-derived vesicles, activated biomaterials, nanodrugs delivery systems, biomedicine applications
