Nature Communications (Feb 2022)
The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system
- Chang Hoon Ji,
- Hee Yeon Kim,
- Min Ju Lee,
- Ah Jung Heo,
- Daniel Youngjae Park,
- Sungsu Lim,
- Seulgi Shin,
- Woo Seung Yang,
- Chang An Jung,
- Kun Young Kim,
- Eun Hye Jeong,
- Sun Ho Park,
- Su Bin Kim,
- Su Jin Lee,
- Jeong Eun Na,
- Ji In Kang,
- Hyung Min Chi,
- Hyun Tae Kim,
- Yun Kyung Kim,
- Bo Yeon Kim,
- Yong Tae Kwon
Affiliations
- Chang Hoon Ji
- Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University
- Hee Yeon Kim
- Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University
- Min Ju Lee
- Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University
- Ah Jung Heo
- Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University
- Daniel Youngjae Park
- Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University
- Sungsu Lim
- Convergence Research Center for Brain Science, Brain Science Institute, Korea Institute of Science and Technology (KIST)
- Seulgi Shin
- Convergence Research Center for Brain Science, Brain Science Institute, Korea Institute of Science and Technology (KIST)
- Woo Seung Yang
- Convergence Research Center for Brain Science, Brain Science Institute, Korea Institute of Science and Technology (KIST)
- Chang An Jung
- AUTOTAC Bio Inc.
- Kun Young Kim
- AUTOTAC Bio Inc.
- Eun Hye Jeong
- AUTOTAC Bio Inc.
- Sun Ho Park
- AUTOTAC Bio Inc.
- Su Bin Kim
- Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University
- Su Jin Lee
- Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University
- Jeong Eun Na
- AUTOTAC Bio Inc.
- Ji In Kang
- Anticancer Agents Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang
- Hyung Min Chi
- Department of Chemisty, Pohang University of Science and Technology
- Hyun Tae Kim
- AUTOTAC Bio Inc.
- Yun Kyung Kim
- Convergence Research Center for Brain Science, Brain Science Institute, Korea Institute of Science and Technology (KIST)
- Bo Yeon Kim
- Anticancer Agents Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang
- Yong Tae Kwon
- Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University
- DOI
- https://doi.org/10.1038/s41467-022-28520-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Targeted protein degradation is a promising approach for basic research and therapeutic applications. Here, the authors develop a targeted protein degradation platform called AUTOTAC to degrade oncoproteins and neurodegeneration-associated proteins via the p62-dependent autophagy-lysosome system.
