The NIH Extracellular RNA Communication Consortium

Alexandra M. Ainsztein; Philip J. Brooks; Vivien G. Dugan; Aniruddha Ganguly; Max Guo; T. Kevin Howcroft; Christine A. Kelley; Lillian S. Kuo; Patricia A. Labosky; Rebecca Lenzi; George A. McKie; Suresh Mohla; Dena Procaccini; Matthew Reilly; John S. Satterlee; Pothur R. Srinivas; Elizabeth Stansell Church; Margaret Sutherland; Danilo A. Tagle; Jessica M. Tucker; Sundar Venkatachalam

doi:10.3402/jev.v4.27493

Journal of Extracellular Vesicles (Aug 2015)

The NIH Extracellular RNA Communication Consortium

Alexandra M. Ainsztein,
Philip J. Brooks,
Vivien G. Dugan,
Aniruddha Ganguly,
Max Guo,
T. Kevin Howcroft,
Christine A. Kelley,
Lillian S. Kuo,
Patricia A. Labosky,
Rebecca Lenzi,
George A. McKie,
Suresh Mohla,
Dena Procaccini,
Matthew Reilly,
John S. Satterlee,
Pothur R. Srinivas,
Elizabeth Stansell Church,
Margaret Sutherland,
Danilo A. Tagle,
Jessica M. Tucker,
Sundar Venkatachalam

Affiliations

Alexandra M. Ainsztein: Division of Cell Biology and Biophysics, National Institute of General Medical Sciences (NIGMS), Bethesda, MD, USA
Philip J. Brooks: Division of Clinical Innovation, National Center for Advancing Translational Sciences (NCATS), Bethesda, MD, USA
Vivien G. Dugan: Office of Genomics and Advanced Technologies, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), Rockville, MD, USA
Aniruddha Ganguly: Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute (NCI), Rockville, MD, USA
Max Guo: Genetics and Cell Biology Branch, Division of Aging Biology, National Institute on Aging (NIA), Bethesda, MD, USA
T. Kevin Howcroft: Division of Cancer Biology, Cancer Immunology, Hematology, and Etiology Branch, National Cancer Institute (NCI), Rockville, MD, USA
Christine A. Kelley: Division of Discovery Science and Technology, National Institute of Biomedical Imaging and Bioengineering (NIBIB), Bethesda, MD, USA
Lillian S. Kuo: National Center for Advancing Translational Science (NCATS), Bethesda, MD, USA
Patricia A. Labosky: Office of Strategic Coordination, Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI), National Institutes of Health (NIH), Bethesda, MD, USA
Rebecca Lenzi: Office of Strategic Coordination, Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI), National Institutes of Health (NIH), Bethesda, MD, USA
George A. McKie: Ocular Infection, Inflammation, and Immunology, National Eye Institute (NEI), Rockville, MD, USA
Suresh Mohla: Division of Cancer Biology, Tumor Biology and Metastasis Branch (TBMB), National Cancer Institute (NCI), Rockville, MD, USA
Dena Procaccini: National Institute on Drug Abuse (NIDA), Rockville, MD, USA
Matthew Reilly: Division of Neuroscience & Behavior, National Institute on Alcohol Abuse and Alcoholism (NIAAA), Rockville, MD, USA
John S. Satterlee: National Institute on Drug Abuse (NIDA), Rockville, MD, USA
Pothur R. Srinivas: Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute (NHLBI), Bethesda, MD, USA
Elizabeth Stansell Church: Pathogenesis and Basic Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases (NIAID), Rockville, MD, USA
Margaret Sutherland: Neurodegeneration Cluster, National Institute of Neurological Disorders and Stroke (NINDS), Rockville, MD, USA
Danilo A. Tagle: National Center for Advancing Translational Science (NCATS), Bethesda, MD, USA
Jessica M. Tucker: National Institute of Biomedical Imaging and Bioengineering (NIBIB), Bethesda, MD, USA
Sundar Venkatachalam: Integrative Biology and Infectious Diseases Branch, National Institute of Dental and Craniofacial Research (NIDCR), Bethesda, MD, USA

DOI: https://doi.org/10.3402/jev.v4.27493
Journal volume & issue: Vol. 4, no. 0
pp. 1 – 6

Abstract

Read online

The Extracellular RNA (exRNA) Communication Consortium, funded as an initiative of the NIH Common Fund, represents a consortium of investigators assembled to address the critical issues in the exRNA research arena. The overarching goal is to generate a multi-component community resource for sharing fundamental scientific discoveries, protocols, and innovative tools and technologies. The key initiatives include (a) generating a reference catalogue of exRNAs present in body fluids of normal healthy individuals that would facilitate disease diagnosis and therapies, (b) defining the fundamental principles of exRNA biogenesis, distribution, uptake, and function, as well as development of molecular tools, technologies, and imaging modalities to enable these studies, (c) identifying exRNA biomarkers of disease, (d) demonstrating clinical utility of exRNAs as therapeutic agents and developing scalable technologies required for these studies, and (e) developing a community resource, the exRNA Atlas, to provide the scientific community access to exRNA data, standardized exRNA protocols, and other useful tools and technologies generated by funded investigators.

Published in Journal of Extracellular Vesicles

ISSN: 2001-3078 (Online)
Publisher: Wiley
Country of publisher: United States
LCC subjects: Science: Biology (General): Cytology
Website: https://onlinelibrary.wiley.com/journal/20013078

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