Haematologica (Mar 2015)

ASXL1 mutations in younger adult patients with acute myeloid leukemia: a study by the German-Austrian Acute Myeloid Leukemia Study Group

  • Peter Paschka,
  • Richard F. Schlenk,
  • Verena I. Gaidzik,
  • Julia K. Herzig,
  • Teresa Aulitzky,
  • Lars Bullinger,
  • Daniela Späth,
  • Veronika Teleanu,
  • Andrea Kündgen,
  • Claus-Henning Köhne,
  • Peter Brossart,
  • Gerhard Held,
  • Heinz-A. Horst,
  • Mark Ringhoffer,
  • Katharina Götze,
  • David Nachbaur,
  • Thomas Kindler,
  • Michael Heuser,
  • Felicitas Thol,
  • Arnold Ganser,
  • Hartmut Döhner,
  • Konstanze Döhner

DOI
https://doi.org/10.3324/haematol.2014.114157
Journal volume & issue
Vol. 100, no. 3

Abstract

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We studied 1696 patients (18 to 61 years) with acute myeloid leukemia for ASXL1 mutations and identified these mutations in 103 (6.1%) patients. ASXL1 mutations were associated with older age (P