Neutralization mechanism of a highly potent antibody against Zika virus

Shuijun Zhang; Victor A. Kostyuchenko; Thiam-Seng Ng; Xin-Ni Lim; Justin S. G. Ooi; Sebastian Lambert; Ter Yong Tan; Douglas G. Widman; Jian Shi; Ralph S. Baric; Shee-Mei Lok

doi:10.1038/ncomms13679

Nature Communications (Nov 2016)

Neutralization mechanism of a highly potent antibody against Zika virus

Shuijun Zhang,
Victor A. Kostyuchenko,
Thiam-Seng Ng,
Xin-Ni Lim,
Justin S. G. Ooi,
Sebastian Lambert,
Ter Yong Tan,
Douglas G. Widman,
Jian Shi,
Ralph S. Baric,
Shee-Mei Lok

Affiliations

Shuijun Zhang: Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
Victor A. Kostyuchenko: Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
Thiam-Seng Ng: Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
Xin-Ni Lim: Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
Justin S. G. Ooi: Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
Sebastian Lambert: Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
Ter Yong Tan: Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
Douglas G. Widman: Department of Epidemiology, University of North Carolina at Chapel Hill
Jian Shi: Centre for BioImaging Sciences, National University of Singapore
Ralph S. Baric: Department of Epidemiology, University of North Carolina at Chapel Hill
Shee-Mei Lok: Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School

DOI: https://doi.org/10.1038/ncomms13679
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 7

Abstract

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There is a pressing need for therapeutic agents against Zika virus (ZIKV). Here the authors present cryoEM structures of a neutralizing antibody (C10) complexed with ZIKV that show C10 preventing structural changes required for virus entry into the cell, suggesting it might be effective in treating Zika infections.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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