Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites

Hanwei Fang; Ana Rita Gomes; Natacha Klages; Paco Pino; Bohumil Maco; Eloise M. Walker; Zenon A. Zenonos; Fiona Angrisano; Jake Baum; Christian Doerig; David A. Baker; Oliver Billker; Mathieu Brochet

doi:10.1038/s41467-018-06733-w

Nature Communications (Oct 2018)

Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites

Hanwei Fang,
Ana Rita Gomes,
Natacha Klages,
Paco Pino,
Bohumil Maco,
Eloise M. Walker,
Zenon A. Zenonos,
Fiona Angrisano,
Jake Baum,
Christian Doerig,
David A. Baker,
Oliver Billker,
Mathieu Brochet

Affiliations

Hanwei Fang: Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva
Ana Rita Gomes: Malaria Programme, Wellcome Trust Sanger Institute
Natacha Klages: Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva
Paco Pino: Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva
Bohumil Maco: Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva
Eloise M. Walker: Faculty of Infectious and Tropical Diseases, London School of Hygiene &Tropical Medicine
Zenon A. Zenonos: Malaria Programme, Wellcome Trust Sanger Institute
Fiona Angrisano: Department of Life Sciences, Imperial College London
Jake Baum: Department of Life Sciences, Imperial College London
Christian Doerig: Department of Microbiology, Infection & Immunity Program, Monash Biomedicine Discovery Institute, Monash University
David A. Baker: Faculty of Infectious and Tropical Diseases, London School of Hygiene &Tropical Medicine
Oliver Billker: The Laboratory for Molecular Infection Medicine Sweden (MIMS), Department of Molecular Biology, Umeå University
Mathieu Brochet: Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva

DOI: https://doi.org/10.1038/s41467-018-06733-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Despite functional optimisation during evolution of parasitism, most members of a calcium dependent protein kinase (CDPK) family show genetic redundancy in Plasmodium. Here, the authors screen 294 genetic interactions among protein kinases in Plasmodium and show how some CDPKs functionally interact to control motility and host cell invasion.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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