Frontiers in Oncology (Mar 2020)

OSeac: An Online Survival Analysis Tool for Esophageal Adenocarcinoma

  • Qiang Wang,
  • Zhongyi Yan,
  • Linna Ge,
  • Ning Li,
  • Mengsi Yang,
  • Xiaoxiao Sun,
  • Longxiang Xie,
  • Guosen Zhang,
  • Wan Zhu,
  • Yunlong Wang,
  • Yongqiang Li,
  • Xianzhe Li,
  • Xiangqian Guo

DOI
https://doi.org/10.3389/fonc.2020.00315
Journal volume & issue
Vol. 10

Abstract

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Esophageal Adenocarcinoma (EAC) is one of the most common gastrointestinal tumors in the world. However, molecular prognostic systems are still lacking for EAC. Hence, we developed an Online consensus Survival analysis web server for Esophageal Adenocarcinoma (OSeac), to centralize published gene expression data and clinical follow up data of EAC patients from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). OSeac includes 198 EAC cases with gene expression profiling and relevant clinical long-term follow-up data, and employs the Kaplan Meier (KM) survival plot with hazard ratio (HR) and log rank test to estimate the prognostic potency of genes of interests for EAC patients. Moreover, we have determined the reliability of OSeac by using previously reported prognostic biomarkers such as DKK3, CTO1, and TXNIP. OSeac is free and publicly accessible at http://bioinfo.henu.edu.cn/EAC/EACList.jsp.

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