南极磷虾油的营养特性及其改善 骨质疏松症的研究进展Research progress on nutritional properties of Antarctic krill oil and its improvement on osteoporosis

Abstract

南极磷虾油（AKO）是一种新型的海洋功能性油脂。为了促进AKO的临床应用，在综述AKO营养组成的基础上，对AKO改善骨质疏松症的作用机制进行了阐述，并对未来的重点工作进行了展望。AKO富含磷脂、n-3型多不饱和脂肪酸（n-3 PUFA）、虾青素、α-生育酚等多种活性因子。AKO改善骨质疏松症的作用机制有3种，即抑制破骨细胞产生、促进骨细胞形成和调控骨髓间充质干细胞。在AKO未来的深入研究中，应聚焦于大规模临床研究、标准剂量和长期效果验证等方面。Antarctic krill oil (AKO) is a novel marine functional lipid. In order to promote the clinical application of AKO, the nutritional composition of AKO was summarized, the mechanism of AKO in improving osteoporosis was described, and the future key work was prospected. AKO is rich in phospholipids, n-3 polyunsaturated fatty acids (n-3 PUFA), astaxanthin, α-tocopherol, and other bioactive factors. There are three mechanisms for AKO to improve osteoporosis, namely, inhibiting osteoclastogenesis, promoting osteoblastogenesis, and regulating bone marrow mesenchymal stem cells. Future in-depth investigations into AKO should focus on large-scale clinical trials, standardized dosages, and long-term efficacy validation.

Keywords

• 南极磷虾油；脂质；脂质伴随物;n-3型多不饱和脂肪酸；骨质疏松症
• antarctic krill oil; lipid; lipid concomitant; n-3 polyunsaturated fatty acid; osteoporosis