Enterococcal PrgU Provides Additional Regulation of Pheromone-Inducible Conjugative Plasmids

Lena Lassinantti; Martha I. Camacho; Rebecca J. B. Erickson; Julia L. E. Willett; Nicholas R. De Lay; Josy ter Beek; Gary M. Dunny; Peter J. Christie; Ronnie P.-A. Berntsson

doi:10.1128/mSphere.00264-21

mSphere (Jun 2021)

Enterococcal PrgU Provides Additional Regulation of Pheromone-Inducible Conjugative Plasmids

Lena Lassinantti,
Martha I. Camacho,
Rebecca J. B. Erickson,
Julia L. E. Willett,
Nicholas R. De Lay,
Josy ter Beek,
Gary M. Dunny,
Peter J. Christie,
Ronnie P.-A. Berntsson

Affiliations

Lena Lassinantti: ORCiD; Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden
Martha I. Camacho: Department of Microbiology and Molecular Genetics, McGovern Medical School, Houston, Texas, USA
Rebecca J. B. Erickson: Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Julia L. E. Willett: Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Nicholas R. De Lay: Department of Microbiology and Molecular Genetics, McGovern Medical School, Houston, Texas, USA
Josy ter Beek: ORCiD; Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden
Gary M. Dunny: Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Peter J. Christie: Department of Microbiology and Molecular Genetics, McGovern Medical School, Houston, Texas, USA
Ronnie P.-A. Berntsson: ORCiD; Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden

DOI: https://doi.org/10.1128/mSphere.00264-21
Journal volume & issue: Vol. 6, no. 3

Abstract

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Bacteria utilize type 4 secretion systems (T4SS) to efficiently transfer DNA between donor and recipient cells, thereby spreading genes encoding antibiotic resistance as well as various virulence factors. Regulation of expression of the T4SS proteins and surface adhesins in Gram-positive bacteria is crucial, as some of these are highly toxic to the cell.

Published in mSphere

ISSN: 2379-5042 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msphere

About the journal