Drug Design, Development and Therapy (Jun 2023)
CAR T Cell Therapy: Remedies of Current Challenges in Design, Injection, Infiltration and Working
Abstract
Yuxuan Zhu,1,2 Jianguo Feng,2 Rongxue Wan,2,3 Wenhua Huang2– 4 1The First Clinical Medical School, Southern Medical University, Guangzhou, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, People’s Republic of China; 3Affiliated Hospital of Guangdong Medical University, Zhanjiang, People’s Republic of China; 4Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangzhou, People’s Republic of ChinaCorrespondence: Rongxue Wan; Wenhua Huang, Email [email protected]; [email protected]: Chimeric antigen receptor (CAR) T cell therapy, as an innovative immunotherapy, plays a huge role in current cancer therapy. Although CAR T cell therapy has demonstrated therapeutic effects in some subtypes of B cell leukemia or lymphoma, there are many challenges that limit the therapeutic efficacy of CAR T cells in solid tumors. And how to efficiently transport CAR T cells to tumor tissues is a continuing concern for us. In this review, experiments have been extensively studied and compared. We finally compared the influence of different injection methods on therapeutic efficacy. We also carefully explored the difficulties of designing, homing, and working of CAR T cells, and ultimately came up with better solutions for each process to help CAR T cells reach tumor tissue more efficiently and quickly. These results will have significant implications for guiding CAR T cell therapy in cancer treatment.Keywords: immunotherapy, CAR T cells, metastasis, infiltration, tumor microenvironment
