Nutrition Journal (Jan 2011)

Relationship of Adiposity and Insulin Resistance Mediated by Inflammation in a Group of Overweight and Obese Chilean Adolescents

  • Leiva Laura,
  • Blanco Estela,
  • Díaz Erik,
  • Gahagan Sheila,
  • Reyes Marcela,
  • Lera Lydia,
  • Burrows Raquel

DOI
https://doi.org/10.1186/1475-2891-10-4
Journal volume & issue
Vol. 10, no. 1
p. 4

Abstract

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Abstract The mild chronic inflammatory state associated with obesity may be an important link between adiposity and insulin resistance (IR). In a sample of 137 overweight and obese Chilean adolescents, we assessed associations between high-sensitivity C-reactive protein (hs-CRP), IR and adiposity; explored sex differences; and evaluated whether hs-CRP mediated the relationship between adiposity and IR. Positive relationships between hs-CRP, IR and 2 measures of adiposity were found. Hs-CRP was associated with waist circumference (WC) in boys and fat mass index (FMI) in girls. Using path analysis, we found that hs-CRP mediated the relationship between adiposity (WC and FMI) and the homeostatic model assessment of insulin resistance (HOMA-IR) (p