How lung cancer cells change identity

eLife (Aug 2021)

Affiliations

Mitchell S von Itzstein: ORCiD; Department of Internal Medicine, Division of Hematology and Oncology, the Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, United States
Benjamin J Drapkin: ORCiD; Department of Internal Medicine, Division of Hematology and Oncology, the Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, United States
John D Minna: ORCiD; Department of Internal Medicine, Division of Hematology and Oncology, the Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, United States

Abstract

Changes in MAPK signaling allow lung cancer cells to transition between lineages that respond differently to treatment.