Anti-Liver membrane Antibody predict outcome of Autoimmune Hepatitis

Abstract

Background: Autoantibodies against liver membrane are the specific autoantibodies found in AIH. Cytochrome P450 1A2 has been identified as the target autoantigen for these autoantibodies The aim of the study : is to evaluate the prevalence and clinical relevance of LMA in AIH Methods: The study was performed on 73 Iraqi patients with chronic active hepatitis (CAH) of unknown cause , attending the teaching hospital for gastroenterology and liver disease in a period between November 2003 and July 2004. Anti-liver membrane antibodies were studied by IFA technique. Results: LMA was detected in the sera of 28(57.14)and 3(37.5%) patients with type 1 and type 3 AIH respectively, but never in the sera of healthy group . Conclusion: It was concluded that LMA is present in type-1 and type-3 AIH but not in sera of patients with type-2 or in healthy control group.

Keywords

• Anti-Liver membrane