Endovascular progenitors infiltrate melanomas and differentiate towards a variety of vascular beds promoting tumor metastasis

Prudence Donovan; Jatin Patel; James Dight; Ho Yi Wong; Seen-Ling Sim; Valentine Murigneux; Mathias Francois; Kiarash Khosrotehrani

doi:10.1038/s41467-018-07961-w

Nature Communications (Jan 2019)

Endovascular progenitors infiltrate melanomas and differentiate towards a variety of vascular beds promoting tumor metastasis

Prudence Donovan,
Jatin Patel,
James Dight,
Ho Yi Wong,
Seen-Ling Sim,
Valentine Murigneux,
Mathias Francois,
Kiarash Khosrotehrani

Affiliations

Prudence Donovan: Translational Research Institute, UQ Diamantina Institute, The University of Queensland
Jatin Patel: Translational Research Institute, UQ Diamantina Institute, The University of Queensland
James Dight: Translational Research Institute, UQ Diamantina Institute, The University of Queensland
Ho Yi Wong: Translational Research Institute, UQ Diamantina Institute, The University of Queensland
Seen-Ling Sim: Translational Research Institute, UQ Diamantina Institute, The University of Queensland
Valentine Murigneux: Translational Research Institute, UQ Diamantina Institute, The University of Queensland
Mathias Francois: Institute of Molecular Biosciences, The University of Queensland
Kiarash Khosrotehrani: Translational Research Institute, UQ Diamantina Institute, The University of Queensland

DOI: https://doi.org/10.1038/s41467-018-07961-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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The contribution of endothelial progenitor cells to tumor angiogenesis is controversial. Here, the authors trace the lineage differentiation of endovascular progenitor cells and demonstrate their functional importance in tumor vascularization and progression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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