Paraventricular hypothalamus mediates diurnal rhythm of metabolism

Eun Ran Kim; Yuanzhong Xu; Ryan M. Cassidy; Yungang Lu; Yongjie Yang; Jinbin Tian; De-Pei Li; Rachel Van Drunen; Aleix Ribas-Latre; Zhao-Lin Cai; Mingshan Xue; Benjamin R. Arenkiel; Kristin Eckel-Mahan; Yong Xu; Qingchun Tong

doi:10.1038/s41467-020-17578-7

Nature Communications (Jul 2020)

Paraventricular hypothalamus mediates diurnal rhythm of metabolism

Eun Ran Kim,
Yuanzhong Xu,
Ryan M. Cassidy,
Yungang Lu,
Yongjie Yang,
Jinbin Tian,
De-Pei Li,
Rachel Van Drunen,
Aleix Ribas-Latre,
Zhao-Lin Cai,
Mingshan Xue,
Benjamin R. Arenkiel,
Kristin Eckel-Mahan,
Yong Xu,
Qingchun Tong

Affiliations

Eun Ran Kim: Brown Foundation Institute of Molecular Medicine, University of Texas McGovern Medical School
Yuanzhong Xu: Brown Foundation Institute of Molecular Medicine, University of Texas McGovern Medical School
Ryan M. Cassidy: Brown Foundation Institute of Molecular Medicine, University of Texas McGovern Medical School
Yungang Lu: Brown Foundation Institute of Molecular Medicine, University of Texas McGovern Medical School
Yongjie Yang: Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
Jinbin Tian: Brown Foundation Institute of Molecular Medicine, University of Texas McGovern Medical School
De-Pei Li: Department of Critical Care and Respiratory Care, Division of Anesthesiology, Critical Care and Pain Medicine, University of Texas MD Anderson Cancer Center
Rachel Van Drunen: Brown Foundation Institute of Molecular Medicine, University of Texas McGovern Medical School
Aleix Ribas-Latre: Brown Foundation Institute of Molecular Medicine, University of Texas McGovern Medical School
Zhao-Lin Cai: Department of Neuroscience, Baylor College of Medicine
Mingshan Xue: Department of Neuroscience, Baylor College of Medicine
Benjamin R. Arenkiel: Department of Neuroscience, Baylor College of Medicine
Kristin Eckel-Mahan: Brown Foundation Institute of Molecular Medicine, University of Texas McGovern Medical School
Yong Xu: Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
Qingchun Tong: Brown Foundation Institute of Molecular Medicine, University of Texas McGovern Medical School

DOI: https://doi.org/10.1038/s41467-020-17578-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

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Defective rhythmic metabolism is associated with high-fat diet feeding and obesity. The authors show that the clock gene BMAL1 drives paraventricular hypothalamic neuron activity via rhythmic GABAergic neurotransmission, and that this mediates diurnal metabolism and diet-induced obesity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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