Efficacy of Presepsin as a Biomarker of Sepsis and Its Prognostic Value for Prediction of Mortality

Abstract

Aim:We aimed to determine the efficacy of presepsin (PRE) as a biomarker of sepsis and to asssess its prognostic value for prediction of mortality were determined.Methods:Selected clinical data of 21 patients admitted to intensive care unit for systemic inflammatory response syndrome (SIRS), sepsis and septic shock were collected. APACHE-II score, blood culture results and WBC and CRP measured at baseline, procalcitonin (PCT) and PRE measured at baseline and on days 2, 4, and 7, and mortality of patients were recorded.Results:Compared to SIRS, sepsis and septic shock caused comparable increases in the APACHE II scores and mortality rates. The PRE values of the septic shock patients were significantly higher as compared to the sepsis and the SIRS patients at baseline and on day 2. Moderate or high correlations among both the PCT and PRE values measured at baseline and on days 2, 4, and 7 were detected. Overall, the diagnostic and prognostic efficacies of PRE were comparable to those of PCT.Conclusions:During differential diagnosis, follow-up and prediction of mortality risk of patients for SIRS, sepsis and septic shock, findings of current study support that PRE possesses a merit to be used as a biomarker with comparable efficacy with PCT.

Keywords

• systemic inflammatory response syndrome (sirs)
• sepsis
• septic shock
• apache-ii
• presepsin
• procalcitonin
• c-reactive protein (crp)
• white blood count (wbc)