A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

Devika Agarwal; Cynthia Sandor; Viola Volpato; Tara M. Caffrey; Jimena Monzón-Sandoval; Rory Bowden; Javier Alegre-Abarrategui; Richard Wade-Martins; Caleb Webber

doi:10.1038/s41467-020-17876-0

Nature Communications (Aug 2020)

A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

Devika Agarwal,
Cynthia Sandor,
Viola Volpato,
Tara M. Caffrey,
Jimena Monzón-Sandoval,
Rory Bowden,
Javier Alegre-Abarrategui,
Richard Wade-Martins,
Caleb Webber

Affiliations

Devika Agarwal: Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
Cynthia Sandor: UK Dementia Research Institute, Cardiff University
Viola Volpato: UK Dementia Research Institute, Cardiff University
Tara M. Caffrey: Oxford Parkinson’s Disease Centre, Department of Physiology, Anatomy, Genetics, University of Oxford
Jimena Monzón-Sandoval: UK Dementia Research Institute, Cardiff University
Rory Bowden: Wellcome Trust Centre for Human Genetics
Javier Alegre-Abarrategui: Oxford Parkinson’s Disease Centre, Department of Physiology, Anatomy, Genetics, University of Oxford
Richard Wade-Martins: Oxford Parkinson’s Disease Centre, Department of Physiology, Anatomy, Genetics, University of Oxford
Caleb Webber: Oxford Parkinson’s Disease Centre, Department of Physiology, Anatomy, Genetics, University of Oxford

DOI: https://doi.org/10.1038/s41467-020-17876-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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The substantia nigra is important in neurological disease, particularly movement disorders. Here the authors provide a single cell transcriptomic atlas for the human substantia nigra.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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