Concise and Gram-Scale Total Synthesis of Lansiumamides A and B and Alatamide

Abstract

The total synthesis of potent anti-obesity lansiumamide B was accomplished in four steps using commercially available materials. The synthetic strategy, featured with copper-catalyzed Buchwald coupling, is concise, convergent, practical and can be carried out on a one-gram scale. This approach could give either Z- or E-configured enamide moiety in natural products with absolute stereocontrol and was applied in the total synthesis of natural products.

Keywords

• total synthesis
• lansiumamide
• alatamide
• copper-catalyzed buchwald coupling