Matrix mechanics regulates epithelial defence against cancer by tuning dynamic localization of filamin

Shilpa P. Pothapragada; Praver Gupta; Soumi Mukherjee; Tamal Das

doi:10.1038/s41467-021-27896-z

Nature Communications (Jan 2022)

Matrix mechanics regulates epithelial defence against cancer by tuning dynamic localization of filamin

Shilpa P. Pothapragada,
Praver Gupta,
Soumi Mukherjee,
Tamal Das

Affiliations

Shilpa P. Pothapragada: TIFR Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research Hyderabad (TIFR-H)
Praver Gupta: TIFR Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research Hyderabad (TIFR-H)
Soumi Mukherjee: TIFR Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research Hyderabad (TIFR-H)
Tamal Das: TIFR Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research Hyderabad (TIFR-H)

DOI: https://doi.org/10.1038/s41467-021-27896-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Epithelial cells have the ability to competitively remove potentially cancerous cells from the tissue. Here the authors discover that pathological stiffening of extracellular matrix leads to the loss of this basic epithelial defence against cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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