Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy

Kaiyuan Ni; Guangxu Lan; Samuel S. Veroneau; Xiaopin Duan; Yang Song; Wenbin Lin

doi:10.1038/s41467-018-06655-7

Nature Communications (Oct 2018)

Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy

Kaiyuan Ni,
Guangxu Lan,
Samuel S. Veroneau,
Xiaopin Duan,
Yang Song,
Wenbin Lin

Affiliations

Kaiyuan Ni: Department of Chemistry, The University of Chicago
Guangxu Lan: Department of Chemistry, The University of Chicago
Samuel S. Veroneau: Department of Chemistry, The University of Chicago
Xiaopin Duan: Department of Chemistry, The University of Chicago
Yang Song: Department of Chemistry, The University of Chicago
Wenbin Lin: Department of Chemistry, The University of Chicago

DOI: https://doi.org/10.1038/s41467-018-06655-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

Read online

Photosensitizers delivered to mitochondria of cancer cells can enhance photodynamic therapy. Here, the authors report mitochondria-targeted radiation therapy and radiodynamic therapy of colorectal cancer models with a cationic nanoscale metal-organic framework to overcome shallow light penetration of Ru-based photosensitizers.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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