Synthesis of 2-azetidinones substituted quinoline derivative

Abstract

Acetanilide is converted into 2-chloro-3-formyl quinoline by reacting with DMF-POCl3 at 80-90ºC and then condensed with aromatic primary amines to give Schiff bases (3a-3c). These Schiff bases are then reacted with acid chlorides in the presence of base in toluene to give 1, 3, 4-substituted 2-azetidinones.

Keywords

• acetanilide
• 2-chloro-3-formyl quinoline
• aromatic amine
• acid chloride
• tri-n-butylamine
• 2-azetidinone