Communications Biology (May 2021)

Proline codon pair selection determines ribosome pausing strength and translation efficiency in bacteria

  • Ralph Krafczyk,
  • Fei Qi,
  • Alina Sieber,
  • Judith Mehler,
  • Kirsten Jung,
  • Dmitrij Frishman,
  • Jürgen Lassak

DOI
https://doi.org/10.1038/s42003-021-02115-z
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 11

Abstract

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Ralph Krafczyk et al. demonstrate that both proline codon usage and prolyl-tRNA abundance affect mRNA translation rates of polyproline-motifs in bacteria. These results provide additional insight into sequence-specific translation regulation.