血管性帕金森综合征的研究进展 Progress of Vascular Parkinsonism

Abstract

血管性帕金森综合征（vascular pakinsonism，VP）是脑血管病基础上的一类继发性帕金森 综合征，其症状及认知障碍特点与原发帕金森病有所区别。VP的发病机制尚未明确，可能与皮质下 脑缺血及神经代谢递质变化有关。目前认为与其发病相关的因素可能包括脑血管病危险因素、脑白质 病变、基底节缺血等。本文就VP的流行病学、发病机制、临床特征、影响因素等方面进行综述，以期为 临床诊治提供帮助，改善患者生存质量。 Abstract: Vascular pakinsonism (VP) is a kind of secondary parkinsonism based on cerebrovascular disease. The symptoms and cognitive impairment of VP are different from those of primary Parkinson's disease. The pathogenesis of VP is not clear, which may be related to subcortical cerebral ischemia and neurotransmitter changes. Currently it is believed that factors associated with its pathogenesis may include risk factors of cerebrovascular disease, white matter lesions, basal ganglia ischemia, and etc. This article reviewed the epidemiology, pathogenesis, clinical features, and influencing factors of VP, to provide reference for physicians and improve the quality of life of patients.

Keywords

• 血管性帕金森综合征
• 流行病学
• 发病机制
• 临床症状
• 影响因素
• vascular parkinsonism
• epidemiology
• pathogenesis
• clinical symptoms;influencing factors