A Tissue Engineering Approach to Metastatic Colon Cancer

Samaneh Kamali Sarvestani; Reece K. DeHaan; Paula G. Miller; Shree Bose; Xiling Shen; Michael L. Shuler; Emina H. Huang

iScience (Nov 2020)

A Tissue Engineering Approach to Metastatic Colon Cancer

Samaneh Kamali Sarvestani,
Reece K. DeHaan,
Paula G. Miller,
Shree Bose,
Xiling Shen,
Michael L. Shuler,
Emina H. Huang

Affiliations

Samaneh Kamali Sarvestani: Department of Cancer Biology, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH 44195, USA
Reece K. DeHaan: Department of Cancer Biology, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH 44195, USA; Department of Colon and Rectal Surgery, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH 44195, USA
Paula G. Miller: Departments of Biomedical Engineering, Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14850, USA
Shree Bose: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
Xiling Shen: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
Michael L. Shuler: Departments of Biomedical Engineering, Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14850, USA
Emina H. Huang: Department of Cancer Biology, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH 44195, USA; Department of Colon and Rectal Surgery, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH 44195, USA; Corresponding author

Journal volume & issue: Vol. 23, no. 11
p. 101719

Abstract

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Summary: Colon cancer remains the third most common cause of cancer in the US, and the third most common cause of cancer death. Worldwide, colon cancer is the second most common cause of cancer and cancer deaths. At least 25% of patients still present with metastatic disease, and at least 25-30% will develop metastatic colon cancer in the course of their disease. While chemotherapy and surgery remain the mainstay of treatment, understanding the fundamental cellular niche and mechanical properties that result in metastases would facilitate both prevention and cure. Advances in biomaterials, novel 3D primary human cells, modelling using microfluidics and the ability to alter the physical environment, now offers a unique opportunity to develop and test impactful treatment.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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Abstract

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