Apoptosis-Inducing Action of Antituberculosis Drugs of the Main Group in Vitro

Abstract

The influence of the main antituberculosis drugs (isoniazid, rifampicin, ethambutol) on in vitro apoptosis of peripheral blood lymphocytes from patients with pulmonary tuberculosis was researched. It was shown that all the investigated drugs induced apoptotic death of the lymphocytes in vitro, that could result in disturbance of antigen-specific response formation in pulmonary tuberculosis.

Keywords

• isoniazid
• rifampicin
• ethambutol
• lymphocytes apoptosis
• pulmonary tuberculosis