A combinatorial code of neurexin-3 alternative splicing controls inhibitory synapses via a trans-synaptic dystroglycan signaling loop

Abstract

The presynaptic release probability is a major determinant of synaptic transmission in brain. Here, the authors show that a trans-synaptic signaling complex comprising presynaptic Neurexin-3 and postsynaptic dystroglycan controls the release probability of diverse inhibitory synapses.