MAGIs regulate aPKC to enable balanced distribution of intercellular tension for epithelial sheet homeostasis

Kenji Matsuzawa; Hayato Ohga; Kenta Shigetomi; Tomohiro Shiiya; Masanori Hirashima; Junichi Ikenouchi

doi:10.1038/s42003-021-01874-z

Communications Biology (Mar 2021)

MAGIs regulate aPKC to enable balanced distribution of intercellular tension for epithelial sheet homeostasis

Kenji Matsuzawa,
Hayato Ohga,
Kenta Shigetomi,
Tomohiro Shiiya,
Masanori Hirashima,
Junichi Ikenouchi

Affiliations

Kenji Matsuzawa: Department of Biology, Faculty of Sciences, Kyushu University
Hayato Ohga: Department of Biology, Faculty of Sciences, Kyushu University
Kenta Shigetomi: Department of Biology, Faculty of Sciences, Kyushu University
Tomohiro Shiiya: Division of Pharmacology, Graduate School of Medical and Dental Sciences, Niigata University
Masanori Hirashima: Division of Pharmacology, Graduate School of Medical and Dental Sciences, Niigata University
Junichi Ikenouchi: Department of Biology, Faculty of Sciences, Kyushu University

DOI: https://doi.org/10.1038/s42003-021-01874-z
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 11

Abstract

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Matsuzawa et al. show that adhesion-related molecules MAGI-1 and MAGI-3 localize partitioning defective-3 (Par-3) at apical junctional complexes of cells throughout the epithelial monolayer. This study provides insights into how tension distribution contributes to cellular contractility in epithelial tissue homeostasis.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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