Cluster analysis of molecular components in 100 patients suffering from atopic dermatitis according to the ISAC Multiplex testing

Abstract

Aim: The cluster analysis for the evaluation of the results in Multiplex ISAC test in atopic dermatitis patients. Method: The complete dermatological and allergological examination including the examination of the sensitisation to molecular components with Multiplex ISAC testing was performed. The cluster analysis of molecular components (silhouette value) was processed. Results and conclusion: Altogether 100 atopic dermatitis patients were examined - 48 men, 52 women, the average age 40.9 years. We found 10 clusters with different numbers of molecular components. Fundamental position have the components Phl p 1 (Timothy), Bet v 1 (Birch), Alt a 1 (Alternaria) followed by molecular components of NPC2 family, cystein proteasa, tropomyosin, uteroglobin, lipocalin and PR-10 protein. Our results correspond to the association of molecular components into protein families according to their biochemical structure.

Keywords

• atopic dermatitis
• molecular components
• multiplex isac testing
• protein families
• biochemical structure
• cluster analysis - silhouette