Nature Communications (Sep 2016)
14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
- Simone M. Schoenwaelder,
- Roxane Darbousset,
- Susan L. Cranmer,
- Hayley S. Ramshaw,
- Stephanie L. Orive,
- Sharelle Sturgeon,
- Yuping Yuan,
- Yu Yao,
- James R. Krycer,
- Joanna Woodcock,
- Jessica Maclean,
- Stuart Pitson,
- Zhaohua Zheng,
- Darren C. Henstridge,
- Dianne van der Wal,
- Elizabeth E. Gardiner,
- Michael C. Berndt,
- Robert K. Andrews,
- David E. James,
- Angel F. Lopez,
- Shaun P. Jackson
Affiliations
- Simone M. Schoenwaelder
- Heart Research Institute, Thrombosis Group
- Roxane Darbousset
- Heart Research Institute, Thrombosis Group
- Susan L. Cranmer
- Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct (AMREP), Monash University
- Hayley S. Ramshaw
- Centre for Cancer Biology, SA Pathology and the University of South Australia
- Stephanie L. Orive
- Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct (AMREP), Monash University
- Sharelle Sturgeon
- Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct (AMREP), Monash University
- Yuping Yuan
- Heart Research Institute, Thrombosis Group
- Yu Yao
- Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct (AMREP), Monash University
- James R. Krycer
- Cardiovascular Division, Charles Perkins Centre, The University of Sydney
- Joanna Woodcock
- Centre for Cancer Biology, SA Pathology and the University of South Australia
- Jessica Maclean
- Heart Research Institute, Thrombosis Group
- Stuart Pitson
- Centre for Cancer Biology, SA Pathology and the University of South Australia
- Zhaohua Zheng
- Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct (AMREP), Monash University
- Darren C. Henstridge
- Baker IDI Heart and Diabetes Institute
- Dianne van der Wal
- Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct (AMREP), Monash University
- Elizabeth E. Gardiner
- Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct (AMREP), Monash University
- Michael C. Berndt
- Faculty of Health Sciences, Curtin University
- Robert K. Andrews
- Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct (AMREP), Monash University
- David E. James
- Cardiovascular Division, Charles Perkins Centre, The University of Sydney
- Angel F. Lopez
- Centre for Cancer Biology, SA Pathology and the University of South Australia
- Shaun P. Jackson
- Heart Research Institute, Thrombosis Group
- DOI
- https://doi.org/10.1038/ncomms12862
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 17
Abstract
Platelets express negatively charged phosphatidylserine (PS) on their plasma membrane when propagating coagulation within a developing thrombus. Here the authors show that an adaptor protein 14-3-3 regulates mitochondrial function and PS exposure and thus platelet procoagulant activity, promising a new therapy to reduce thrombosis.
