Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery

Lei Jiang; Sensen Zhou; Xiaoke Zhang; Cheng Li; Shilu Ji; Hui Mao; Xiqun Jiang

doi:10.1038/s41467-021-22594-2

Nature Communications (Apr 2021)

Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery

Lei Jiang,
Sensen Zhou,
Xiaoke Zhang,
Cheng Li,
Shilu Ji,
Hui Mao,
Xiqun Jiang

Affiliations

Lei Jiang: MOE Key Laboratory of High Performance Polymer Materials and Technology, and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University
Sensen Zhou: MOE Key Laboratory of High Performance Polymer Materials and Technology, and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University
Xiaoke Zhang: MOE Key Laboratory of High Performance Polymer Materials and Technology, and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University
Cheng Li: MOE Key Laboratory of High Performance Polymer Materials and Technology, and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University
Shilu Ji: MOE Key Laboratory of High Performance Polymer Materials and Technology, and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University
Hui Mao: Department of Radiology and Imaging Sciences, Emory University
Xiqun Jiang: MOE Key Laboratory of High Performance Polymer Materials and Technology, and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University

DOI: https://doi.org/10.1038/s41467-021-22594-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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Mitochondria are key targets for photothermal and photodynamic treatment for cancer but delivery of therapeutics to these organelles remains a challenge. In this study, authors develop a mitochondrial targeted liposomal delivery platform using a dendritic peptide moiety as a mitochondria targeting moiety and demonstrate its targeting and antitumour efficacy in a mouse model of breast cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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