Nature Communications (Apr 2019)
WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis
- Karol Kaiser,
- Daniel Gyllborg,
- Jan Procházka,
- Alena Salašová,
- Petra Kompaníková,
- Francisco Lamus Molina,
- Rocio Laguna-Goya,
- Tomasz Radaszkiewicz,
- Jakub Harnoš,
- Michaela Procházková,
- David Potěšil,
- Roger A. Barker,
- Ángel Gato Casado,
- Zbyněk Zdráhal,
- Radislav Sedláček,
- Ernest Arenas,
- J. Carlos Villaescusa,
- Vítězslav Bryja
Affiliations
- Karol Kaiser
- Department of Experimental Biology, Faculty of Science, Masaryk University
- Daniel Gyllborg
- Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Jan Procházka
- Czech Centre for Phenogenomics and Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the CAS, v. v. i., Prumyslova 595
- Alena Salašová
- Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Petra Kompaníková
- Department of Experimental Biology, Faculty of Science, Masaryk University
- Francisco Lamus Molina
- Departamento de Anatomía y Radiología, Facultad de medicina, Universidad de Valladolid, Ramón y Cajal 5
- Rocio Laguna-Goya
- John van Geest Centre for Brain Repair and Cambridge Stem Cell Institute, University of Cambridge
- Tomasz Radaszkiewicz
- Department of Experimental Biology, Faculty of Science, Masaryk University
- Jakub Harnoš
- Department of Experimental Biology, Faculty of Science, Masaryk University
- Michaela Procházková
- Czech Centre for Phenogenomics and Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the CAS, v. v. i., Prumyslova 595
- David Potěšil
- Central European Institute of Technology
- Roger A. Barker
- John van Geest Centre for Brain Repair and Cambridge Stem Cell Institute, University of Cambridge
- Ángel Gato Casado
- Departamento de Anatomía y Radiología, Facultad de medicina, Universidad de Valladolid, Ramón y Cajal 5
- Zbyněk Zdráhal
- Central European Institute of Technology
- Radislav Sedláček
- Czech Centre for Phenogenomics and Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the CAS, v. v. i., Prumyslova 595
- Ernest Arenas
- Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- J. Carlos Villaescusa
- Department of Experimental Biology, Faculty of Science, Masaryk University
- Vítězslav Bryja
- Department of Experimental Biology, Faculty of Science, Masaryk University
- DOI
- https://doi.org/10.1038/s41467-019-09298-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
WNTs can signal over long distances but how this arises in the brain is unclear. Here, the authors show that WNT5A is secreted from the choroid plexus of the developing hindbrain (but not the telencephalon) and transported in the CSF with lipoprotein particles in order to control cerebellar morphogenesis.
