Correlation Between Bone Metabolism Indices and Osteoporotic Thoracolumbar Vertebrae Fracture in Postmenopausal Women

Abstract

Pengrui Jing,* Fanqi Kong,* Bin Meng, Shaofeng Yang Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shaofeng Yang; Bin Meng, Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou, Jiangsu, 215006, People’s Republic of China, Email [email protected]; [email protected]: This study aims to explore the correlation between bone metabolism indices and osteoporotic thoracolumbar vertebrae fracture (OTVF) in postmenopausal women.Methods: A total of 447 female patients with postmenopause and underwent OTVF in our hospital were selected as group A. Three hundred eighty-seven out-patients without fractures were selected as group B. Bone metabolism index including the serum levels of total Serum procollagen type N-terminal propeptide (tPINP), the age-related type I cross linked C-telopeptide (β-CTX) and 25-hydroxyvitamin D (25-OHD) were collected and compared. The relation between bone metabolism indices and OTVF was analyzed.Results: The mean tPINP in group A was 61.72 ± 28.43, which was notably higher than group B (P < 0.01). Meanwhile, greater β-CTX were higher founded in group A than group B (0.778 ± 0.316 vs 0.669 ± 0.303 μg/l). However, the 25-OHD in group A was significantly lower than that in group B (P < 0.05). Multivariate logistic regression analysis revealed that the serum level of tPINP (OR: 0.008, P = 0.011), the serum level of β-CTX (OR: 0.805, P = 0.002) and the serum level of 25-OHD (OR: − 0.029, P = 0.003) were independently correlated with postmenopausal OTVF.Conclusion: Bone metabolic markers play an important role in predicting OTVF. As a reflection of bone mass and bone strength, BMD is inadequate in predicting OTVF. High expression of bone metabolism indicators β-CTX, tPINP and relatively low expression of 25-OHD suggest an increased risk of OTVF. Early detection of postmenopausal bone metabolism abnormalities can be used for early intervention to reduce the incidence of OTVF.Keywords: bone metabolism indices, osteoporotic thoracolumbar vertebrae fracture, correlation, risk, postmenopausal women

Keywords

• bone metabolism indices
• osteoporotic thoracolumbar vertebrae fracture
• correlation
• risk；postmenopausal women