Lactate aggravates inflammation through the upregulation of ICAM-1 via GPR81-HSPA12B-mediated signaling in acute lung injury

• Wei Chang,
• Xu Liu,
• Haofei Wang,
• Xingxing Zhu,
• Wei Huang,
• Ling Liu,
• Haibo Qiu,
• Yi Yang,
• Sihan Zhou,
• Xiuyuan Hao

Affiliations

Wei Chang

1 Department of Critical Care Medicine, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China

Xu Liu

2 The Medical School, Southeast University, Nanjing, Jiangsu 210009, China

Haofei Wang

2 The Medical School, Southeast University, Nanjing, Jiangsu 210009, China

Xingxing Zhu

2 The Medical School, Southeast University, Nanjing, Jiangsu 210009, China

Wei Huang

1 Department of Critical Care Medicine, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China

Ling Liu

1 Department of Critical Care Medicine, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China

Haibo Qiu

1 Department of Critical Care Medicine, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China

Yi Yang

1 Department of Critical Care Medicine, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China

Sihan Zhou

Xiuyuan Hao