Журнал микробиологии, эпидемиологии и иммунобиологии (Feb 2017)

COMPLEX IMMUNOGLOBULIN PREPARATION FOR THERAPY OF PERTUSSIS IN YOUNG CHILDREN

  • L. I. Novikova,
  • M. S. Petrova,
  • V. A. Aleshkin,
  • T. A. Skirda,
  • A. V. Volkov,
  • N. S. Matveevskaya,
  • S. S. Bochkareva,
  • T. V. Sinchugova,
  • R. L. Panurina,
  • M. M. Zueva,
  • M. A. Naumova,
  • I. S. Voronova,
  • S. V. Bunin,
  • O. Yu. Borisova,
  • A. S. Pimenova

DOI
https://doi.org/10.36233/0372-9311-2017-1-73-80
Journal volume & issue
Vol. 0, no. 1
pp. 73 – 80

Abstract

Read online

Aim. Study the possibility of inclusion of complex immunoglobulin preparation (CIP) possessing specific activity against pertussis exotoxins into complex therapy of pertussis infection in young children. Materials and methods. 2 groups of children with pertussis younger than 3 years were examined. The main group (50 individuals) received CIP per os - 1 dose 1 - 2 times per day for 5 days, comparison group (34 children) received only basic therapy. Evaluation of clinical effectiveness of CIP was carried out, the content of anti-pertussis class G antibodies and total IgE in patients were studied. Results. A good clinical effectiveness of the preparation was shown, as well as immune modulating activity against humoral immune response to pertussis infection. Conclusion. The detected positive effect of CIP on pertussis course in children has indicated a principally novel use of this per oral drug form.

Keywords