Nature Communications (Mar 2022)
Integrative network analysis of early-stage lung adenocarcinoma identifies aurora kinase inhibition as interceptor of invasion and progression
- Seungyeul Yoo,
- Abhilasha Sinha,
- Dawei Yang,
- Nasser K. Altorki,
- Radhika Tandon,
- Wenhui Wang,
- Deebly Chavez,
- Eunjee Lee,
- Ayushi S. Patel,
- Takashi Sato,
- Ranran Kong,
- Bisen Ding,
- Eric E. Schadt,
- Hideo Watanabe,
- Pierre P. Massion,
- Alain C. Borczuk,
- Jun Zhu,
- Charles A. Powell
Affiliations
- Seungyeul Yoo
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Abhilasha Sinha
- Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai
- Dawei Yang
- Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai
- Nasser K. Altorki
- Department of Cardiothoracic Surgery, Weill Cornell Medicine-New York Presbyterian Hospital
- Radhika Tandon
- School of Medicine, St. George’s University
- Wenhui Wang
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Deebly Chavez
- Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai
- Eunjee Lee
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Ayushi S. Patel
- Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai
- Takashi Sato
- Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai
- Ranran Kong
- Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai
- Bisen Ding
- Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai
- Eric E. Schadt
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Hideo Watanabe
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Pierre P. Massion
- Department of Medicine, Vanderbilt University Medical Center
- Alain C. Borczuk
- Department of Pathology, Weill Cornell Medicine
- Jun Zhu
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Charles A. Powell
- Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-022-29230-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
The molecular factors that drive invasiveness and metastasis in lung adenocarcinoma (LUAD) are not completely understood. Here, the authors use an integrative network approach to identify a gene signature of invasiveness in LUAD, and reveal Aurora kinases as master regulators of invasion.
