Nature Communications (Apr 2020)
Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection
- Emily Adland,
- Jane Millar,
- Nomonde Bengu,
- Maximilian Muenchhoff,
- Rowena Fillis,
- Kenneth Sprenger,
- Vuyokasi Ntlantsana,
- Julia Roider,
- Vinicius Vieira,
- Katya Govender,
- John Adamson,
- Nelisiwe Nxele,
- Christina Ochsenbauer,
- John Kappes,
- Luisa Mori,
- Jeroen van Lobenstein,
- Yeney Graza,
- Kogielambal Chinniah,
- Constant Kapongo,
- Roopesh Bhoola,
- Malini Krishna,
- Philippa C. Matthews,
- Ruth Penya Poderos,
- Marta Colomer Lluch,
- Maria C. Puertas,
- Julia G. Prado,
- Neil McKerrow,
- Moherndran Archary,
- Thumbi Ndung’u,
- Andreas Groll,
- Pieter Jooste,
- Javier Martinez-Picado,
- Marcus Altfeld,
- Philip Goulder
Affiliations
- Emily Adland
- Department of Paediatrics, University of Oxford
- Jane Millar
- Department of Paediatrics, University of Oxford
- Nomonde Bengu
- Umkhuseli Innovation and Research Management
- Maximilian Muenchhoff
- Max von Pettenkofer Institute, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München
- Rowena Fillis
- Umkhuseli Innovation and Research Management
- Kenneth Sprenger
- Umkhuseli Innovation and Research Management
- Vuyokasi Ntlantsana
- Department of Medicine, University of KwaZulu-Natal
- Julia Roider
- German Center for Infection Research (DZIF), Partner site Munich
- Vinicius Vieira
- Department of Paediatrics, University of Oxford
- Katya Govender
- Africa Health Research Institute
- John Adamson
- Africa Health Research Institute
- Nelisiwe Nxele
- HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal
- Christina Ochsenbauer
- Department of Medicine, University of Alabama at Birmingham
- John Kappes
- Department of Medicine, University of Alabama at Birmingham
- Luisa Mori
- Department of Paediatrics, University of Oxford
- Jeroen van Lobenstein
- Stanger Hospital, KwaDukuza
- Yeney Graza
- KwaZulu-Natal Department of Health
- Kogielambal Chinniah
- Mahatma Gandhi Memorial Hospital
- Constant Kapongo
- Queen Nandi Regional Hospital, Empangeni
- Roopesh Bhoola
- Edendale Hospital, Pietermartizburg
- Malini Krishna
- Edendale Hospital, Pietermartizburg
- Philippa C. Matthews
- Nuffield Department of Medicine, University of Oxford
- Ruth Penya Poderos
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP)
- Marta Colomer Lluch
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP)
- Maria C. Puertas
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP)
- Julia G. Prado
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP)
- Neil McKerrow
- KwaZulu-Natal Department of Health
- Moherndran Archary
- Department of Paediatrics, University of KwaZulu-Natal
- Thumbi Ndung’u
- HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal
- Andreas Groll
- TU Dortmund University, Faculty of Statistics
- Pieter Jooste
- Department of Paediatrics, Kimberley Hospital
- Javier Martinez-Picado
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP)
- Marcus Altfeld
- Virus Immunology Unit, Heinrich-Pette-Institut
- Philip Goulder
- Department of Paediatrics, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-020-15632-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 9
Abstract
Sex differences in the immune response to vaccines and infections have been well described in children and adults. Here the authors describe, in a cohort of 177 HIV-infected infants, innate immune sex differences in fetal life that increase female susceptibility to intrauterine HIV infection and increase the chances of subsequent HIV remission in infected males.
