Subgrouping testicular germ cell tumors based on immunotherapy and chemotherapy associated lncRNAs

Jian Cao; Zhizhong Liu; Junbin Yuan; Yanwei Luo; Jinrong Wang; Jianye Liu; Hao Bo; Jie Guo

Heliyon (Jan 2024)

Subgrouping testicular germ cell tumors based on immunotherapy and chemotherapy associated lncRNAs

Jian Cao,
Zhizhong Liu,
Junbin Yuan,
Yanwei Luo,
Jinrong Wang,
Jianye Liu,
Hao Bo,
Jie Guo

Affiliations

Jian Cao: Hunan Cancer Hospital, Department of Urology, The Affiliated Cancer Hospital of Xiangya School of Medicine of Central South University, Changsha, 410013, Hunan, China
Zhizhong Liu: Hunan Cancer Hospital, Department of Urology, The Affiliated Cancer Hospital of Xiangya School of Medicine of Central South University, Changsha, 410013, Hunan, China
Junbin Yuan: Department of Urology, Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China
Yanwei Luo: Department of Blood Transfusion, the Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China
Jinrong Wang: Department of Urology, The Third Xiangya Hospital of Central South University, No.138, Tongzipo Road, Changsha, 410013, Hunan, China
Jianye Liu: Department of Urology, The Third Xiangya Hospital of Central South University, No.138, Tongzipo Road, Changsha, 410013, Hunan, China
Hao Bo: Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, 410078, Hunan, China; NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha, 410078, Hunan, China; Corresponding author. Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Xiangya Road 84, Changsha, 410078, Hunan, China.
Jie Guo: National Institution of Drug Clinical Trial, Xiangya Hospital, Central South University, Changsha, Hunan, China; China National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; International Science and Technology Innovation Cooperation Base for Early Clinical Trials of Biological Agents in Hunan Province, Changsha, Hunan, China; Corresponding author. National Institution of Drug Clinical Trial, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, 410008, Hunan, China.

Journal volume & issue: Vol. 10, no. 2
p. e24320

Abstract

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Testicular germ cell tumors (TGCT) are the most common reproductive system malignancies in men aged 15–44 years, accounting for 95 % of all testicular tumors. Our previous studies have been shown that long non-coding RNAs (lncRNAs), such as LINC00313, TTTY14 and RFPL3S, were associated with development of TGCT. Subgrouping TGCT according to differential expressed lncRNAs and immunological characteristics is helpful to comprehensively describe the characteristics of TGCT and implement precise treatment. In this study, the TGCT transcriptome data in The Cancer Genome Atlas Program (TCGA) database was used to perform consensus clustering analysis to construct a prognostic model for TGCT. TGCT was divided into 3 subtypes C1, C2, and C3 based on the differentially expressed lncRNAs. C1 subtype was sensitive to chemotherapy drugs, while the C2 subtype was not sensitive to chemotherapy drugs, and C3 subtype may benefit from immunotherapy. We defined the C1 subtype as epidermal progression subtype, the C2 subtype as mesenchymal progression subtype, and the C3 subtype as T cell activation subtype. Subgrouping based on differentially expressed genes (DEGs) and immunological characteristics is helpful for the precise treatment of TGCT.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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