Nature Communications (Jun 2021)
Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder
- Masaki Nishioka,
- An-a Kazuno,
- Takumi Nakamura,
- Naomi Sakai,
- Takashi Hayama,
- Kumiko Fujii,
- Koji Matsuo,
- Atsuko Komori,
- Mizuho Ishiwata,
- Yoshinori Watanabe,
- Takashi Oka,
- Nana Matoba,
- Muneko Kataoka,
- Ahmed N. Alkanaq,
- Kohei Hamanaka,
- Takashi Tsuboi,
- Toru Sengoku,
- Kazuhiro Ogata,
- Nakao Iwata,
- Masashi Ikeda,
- Naomichi Matsumoto,
- Tadafumi Kato,
- Atsushi Takata
Affiliations
- Masaki Nishioka
- Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science
- An-a Kazuno
- Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science
- Takumi Nakamura
- Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science
- Naomi Sakai
- Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science
- Takashi Hayama
- Yokohama Mental Clinic Totsuka
- Kumiko Fujii
- Department of Psychiatry, Shiga University of Medical Science
- Koji Matsuo
- Department of Psychiatry, Saitama Medical University
- Atsuko Komori
- Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science
- Mizuho Ishiwata
- Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science
- Yoshinori Watanabe
- Ichigaya Himorogi Clinic
- Takashi Oka
- Juzen Hospital
- Nana Matoba
- Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science
- Muneko Kataoka
- Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science
- Ahmed N. Alkanaq
- Department of Human Genetics, Yokohama City University Graduate School of Medicine
- Kohei Hamanaka
- Department of Human Genetics, Yokohama City University Graduate School of Medicine
- Takashi Tsuboi
- Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo
- Toru Sengoku
- Department of Biochemistry, Yokohama City University Graduate School of Medicine
- Kazuhiro Ogata
- Department of Biochemistry, Yokohama City University Graduate School of Medicine
- Nakao Iwata
- Department of Psychiatry, Fujita Health University
- Masashi Ikeda
- Department of Psychiatry, Fujita Health University
- Naomichi Matsumoto
- Department of Human Genetics, Yokohama City University Graduate School of Medicine
- Tadafumi Kato
- Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science
- Atsushi Takata
- Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science
- DOI
- https://doi.org/10.1038/s41467-021-23453-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
The significance of rare and de novo variants in bipolar disorder is not well understood. Here, the authors have analyzed whole exome/genome data from trios to identify deleterious de novo variants associated with bipolar disorder.
