Assessing the human health risks of perfluorooctane sulfonate by in vivo and in vitro studies

Zhuotong Zeng; Biao Song; Rong Xiao; Guangming Zeng; Jilai Gong; Ming Chen; Piao Xu; Peng Zhang; Maocai Shen; Huan Yi

Environment International (May 2019)

Assessing the human health risks of perfluorooctane sulfonate by in vivo and in vitro studies

Zhuotong Zeng,
Biao Song,
Rong Xiao,
Guangming Zeng,
Jilai Gong,
Ming Chen,
Piao Xu,
Peng Zhang,
Maocai Shen,
Huan Yi

Affiliations

Zhuotong Zeng: Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, PR China
Biao Song: College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, PR China
Rong Xiao: Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, PR China; Corresponding author.
Guangming Zeng: College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, PR China; Corresponding authors at: College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China.
Jilai Gong: College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, PR China; Corresponding authors at: College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China.
Ming Chen: College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, PR China
Piao Xu: College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, PR China
Peng Zhang: College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, PR China
Maocai Shen: College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, PR China
Huan Yi: College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, PR China

Journal volume & issue: Vol. 126
pp. 598 – 610

Abstract

Read online

The wide use of perfluorooctane sulfonate (PFOS) has led to increasing concern about its human health risks over the past decade. In vivo and in vitro studies are important and effective means to ascertain the toxic effects of PFOS on humans and its toxic mechanisms. This article systematically reviews the human health risks of PFOS based on the currently known facts found by in vivo and in vitro studies from 2008 to 2018. Exposure to PFOS has caused hepatotoxicity, neurotoxicity, reproductive toxicity, immunotoxicity, thyroid disruption, cardiovascular toxicity, pulmonary toxicity, and renal toxicity in laboratory animals and many in vitro human systems. These results and related epidemiological studies confirmed the human health risks of PFOS, especially for exposure via food and drinking water. Oxidative stress and physiological process disruption based on fatty acid similarity were widely studied mechanisms of PFOS toxicity. Future research for assessing the human health risks of PFOS is recommended in the chronic toxicity and molecular mechanisms, the application of various omics, and the integration of toxicological and epidemiological data. Keywords: PFOS, Human health risk, In vivo, In vitro

Published in Environment International

ISSN: 0160-4120 (Print)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Geography. Anthropology. Recreation: Environmental sciences
Website: https://www.journals.elsevier.com/environment-international

About the journal