Communications Biology (Jul 2022)

Mesenchymal stem cells exert renoprotection via extracellular vesicle-mediated modulation of M2 macrophages and spleen-kidney network

  • Yuko Shimamura,
  • Kazuhiro Furuhashi,
  • Akihito Tanaka,
  • Munetoshi Karasawa,
  • Tomoya Nozaki,
  • Shintaro Komatsu,
  • Kenshi Watanabe,
  • Asuka Shimizu,
  • Shun Minatoguchi,
  • Makoto Matsuyama,
  • Yuriko Sawa,
  • Naotake Tsuboi,
  • Takuji Ishimoto,
  • Hiroshi I. Suzuki,
  • Shoichi Maruyama

DOI
https://doi.org/10.1038/s42003-022-03712-2
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 16

Abstract

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The renoprotective effects of adipose-derived mesenchymal stem cells (ASCs) are enhanced through the transfer of EVs predominantly to M2 macrophages in the spleen, providing insights into therapeutic avenues for ASCs.