Nature Communications (Sep 2020)
Telomere dysfunction activates YAP1 to drive tissue inflammation
- Deepavali Chakravarti,
- Baoli Hu,
- Xizeng Mao,
- Asif Rashid,
- Jiexi Li,
- Jun Li,
- Wen-ting Liao,
- Elizabeth M. Whitley,
- Prasenjit Dey,
- Pingping Hou,
- Kyle A. LaBella,
- Andrew Chang,
- Guocan Wang,
- Denise J. Spring,
- Pingna Deng,
- Di Zhao,
- Xin Liang,
- Zhengdao Lan,
- Yiyun Lin,
- Sharmistha Sarkar,
- Christopher Terranova,
- Yonathan Lissanu Deribe,
- Sarah E. Blutt,
- Pablo Okhuysen,
- Jianhua Zhang,
- Eduardo Vilar,
- Ole Haagen Nielsen,
- Andrew Dupont,
- Mamoun Younes,
- Kalyani R. Patel,
- Noah F. Shroyer,
- Kunal Rai,
- Mary K. Estes,
- Y. Alan Wang,
- Alison A. Bertuch,
- Ronald A. DePinho
Affiliations
- Deepavali Chakravarti
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Baoli Hu
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Xizeng Mao
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Asif Rashid
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Jiexi Li
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Jun Li
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Wen-ting Liao
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Elizabeth M. Whitley
- Department of Veterinary Medicine & Surgery, The University of Texas MD Anderson Cancer Center
- Prasenjit Dey
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Pingping Hou
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Kyle A. LaBella
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Andrew Chang
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Guocan Wang
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Denise J. Spring
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Pingna Deng
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Di Zhao
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Xin Liang
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Zhengdao Lan
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Yiyun Lin
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Sharmistha Sarkar
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Christopher Terranova
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Yonathan Lissanu Deribe
- Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center
- Sarah E. Blutt
- Department of Molecular Virology and Microbiology, Baylor College of Medicine
- Pablo Okhuysen
- Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center
- Jianhua Zhang
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Eduardo Vilar
- Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center
- Ole Haagen Nielsen
- Department of Gastroenterology, Herlev Hospital, University of Copenhagen
- Andrew Dupont
- Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston
- Mamoun Younes
- Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, McGovern Medical School and Memorial Hermann Hospital-TMC
- Kalyani R. Patel
- Department of Pathology, Texas Children’s Hospital
- Noah F. Shroyer
- Department of Medicine, Section of Gastroenterology and Hepatology, Baylor College of Medicine
- Kunal Rai
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Mary K. Estes
- Department of Molecular Virology and Microbiology, Baylor College of Medicine
- Y. Alan Wang
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Alison A. Bertuch
- Division of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine
- Ronald A. DePinho
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-020-18420-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
How telomere dysfunction is directly linked to inflammation in humans is currently unclear. Here the authors reveal that telomere dysfunction drives activation of the YAP1 transcription factor, up-regulating the pro inflammatory factor, pro-IL-18 thus revealing a link between telomere dysfunction and initiation of intestinal inflammation.
