A mechanistic insight on the biomimetic activity of surface engineered NH2-MIL-125 with α-Asarone for enhanced ROS production in lung cancer cells

Sagnik Mukherjee; Anjali B. Thakkar; Abhay M. Agola; Payal Sargara; Manish Kumar Mishra; R.B. Subramanian; Parth Thakor

Results in Surfaces and Interfaces (Oct 2024)

A mechanistic insight on the biomimetic activity of surface engineered NH2-MIL-125 with α-Asarone for enhanced ROS production in lung cancer cells

Sagnik Mukherjee,
Anjali B. Thakkar,
Abhay M. Agola,
Payal Sargara,
Manish Kumar Mishra,
R.B. Subramanian,
Parth Thakor

Affiliations

Sagnik Mukherjee: Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388 120, Gujarat, India; Department of Applied and Interdisciplinary Sciences, Sardar Patel University, Vallabh Vidyanagar, 388 120, Gujarat, India; Inorganic Material and Catalysis Division, CSIR-Central Salt and Marine Chemicals Research Institute, Bhavnagar, 364002, Gujarat, India; Corresponding author. Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388 120, Gujarat, India.
Anjali B. Thakkar: Department of Biosciences, Sardar Patel Maidan, Satellite Campus, Sardar Patel University, Bakrol-Vadtal Road, Bakrol, Anand, Gujarat, India; Department of Applied and Interdisciplinary Sciences, Sardar Patel University, Vallabh Vidyanagar, 388 120, Gujarat, India
Abhay M. Agola: Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388 120, Gujarat, India
Payal Sargara: Department of Biosciences, Sardar Patel Maidan, Satellite Campus, Sardar Patel University, Bakrol-Vadtal Road, Bakrol, Anand, Gujarat, India
Manish Kumar Mishra: Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388 120, Gujarat, India
R.B. Subramanian: Department of Biosciences, Sardar Patel Maidan, Satellite Campus, Sardar Patel University, Bakrol-Vadtal Road, Bakrol, Anand, Gujarat, India
Parth Thakor: BapubhaiDesaibhai Patel Institute of Paramedical Sciences, Charotar University of Science and Technology, Changa, Gujarat, India; Corresponding author.

Journal volume & issue: Vol. 17
p. 100274

Abstract

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The α-Asarone-loaded on NH2-MIL-125 (AS@AMIL) was demonstrated to be exceptional potential as a chemo dynamic therapeutic agent (CDT) for lung cancer cells (A549), showing superior efficiency as compared to α-Asarone as well as pristine NH2-MIL-125. The loading of α-Asarone was achieved through cation-π interactions between –NH3+ groups of NH2-MIL-125 and the aromatic ring of α-Asarone. This interaction enriches the framework of AS@AMIL with electrons enhancing the basicity of the framework (O-atoms), which substantially accelerates the decomposition of endogenous H2O2 into reactive oxygen species (ROS) to exhibit enhanced CDT activity. The AS@AMIL exhibited ∼a 1.36-fold increase in ROS production (CDT activity) compared to pristine NH2-MIL-125. The study suggests that the loading of aromatic compounds in amine-functionalized MOFs through cation-π interactions (with –NH3+ groups) can enhance the basicity of MOFs for improved chemodynamic therapeutic activity, and such materials can also be promising as catalysts and CO2 adsorbents.

Published in Results in Surfaces and Interfaces

ISSN: 2666-8459 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Chemical technology: Industrial electrochemistry
Website: https://www.journals.elsevier.com/results-in-surfaces-and-interfaces

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