A Combination of Metagenomic and Cultivation Approaches Reveals Hypermutator Phenotypes within Vibrio cholerae-Infected Patients

Inès Levade; Ashraful I. Khan; Fahima Chowdhury; Stephen B. Calderwood; Edward T. Ryan; Jason B. Harris; Regina C. LaRocque; Taufiqur R. Bhuiyan; Firdausi Qadri; Ana A. Weil; B. Jesse Shapiro

doi:10.1128/mSystems.00889-21

mSystems (Aug 2021)

A Combination of Metagenomic and Cultivation Approaches Reveals Hypermutator Phenotypes within Vibrio cholerae-Infected Patients

Inès Levade,
Ashraful I. Khan,
Fahima Chowdhury,
Stephen B. Calderwood,
Edward T. Ryan,
Jason B. Harris,
Regina C. LaRocque,
Taufiqur R. Bhuiyan,
Firdausi Qadri,
Ana A. Weil,
B. Jesse Shapiro

Affiliations

Inès Levade: Department of Biological Sciences, University of Montreal, Montreal, Quebec, Canada
Ashraful I. Khan: Center for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
Fahima Chowdhury: Center for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
Stephen B. Calderwood: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
Edward T. Ryan: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
Jason B. Harris: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
Regina C. LaRocque: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
Taufiqur R. Bhuiyan: ORCiD; Center for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
Firdausi Qadri: Center for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
Ana A. Weil: Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA
B. Jesse Shapiro: ORCiD; Department of Biological Sciences, University of Montreal, Montreal, Quebec, Canada

DOI: https://doi.org/10.1128/mSystems.00889-21
Journal volume & issue: Vol. 6, no. 4

Abstract

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Pathogen evolution within patients can impact phenotypes such as drug resistance and virulence, potentially affecting clinical outcomes. V. choleraeV. cholerae

Published in mSystems

ISSN: 2379-5077 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msystems

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