Frontiers in Neuroscience (Mar 2020)
Predicting Long-Term After-Effects of Theta-Burst Stimulation on Supplementary Motor Network Through One-Session Response
- Gong-Jun Ji,
- Jinmei Sun,
- Jinmei Sun,
- Jinmei Sun,
- Jinmei Sun,
- Pingping Liu,
- Pingping Liu,
- Pingping Liu,
- Junjie Wei,
- Junjie Wei,
- Junjie Wei,
- Dandan Li,
- Dandan Li,
- Dandan Li,
- Xingqi Wu,
- Xingqi Wu,
- Xingqi Wu,
- Lei Zhang,
- Lei Zhang,
- Lei Zhang,
- Fengqiong Yu,
- Fengqiong Yu,
- Fengqiong Yu,
- Tongjian Bai,
- Tongjian Bai,
- Tongjian Bai,
- Chunyan Zhu,
- Chunyan Zhu,
- Chunyan Zhu,
- Yanghua Tian,
- Yanghua Tian,
- Yanghua Tian,
- Kai Wang,
- Kai Wang,
- Kai Wang,
- Kai Wang
Affiliations
- Gong-Jun Ji
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Jinmei Sun
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Jinmei Sun
- Department of Medical Psychology, Chaohu Clinical Medical College, Anhui Medical University, Hefei, China
- Jinmei Sun
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Jinmei Sun
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Pingping Liu
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Pingping Liu
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Pingping Liu
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Junjie Wei
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Junjie Wei
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Junjie Wei
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Dandan Li
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Dandan Li
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Dandan Li
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Xingqi Wu
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Xingqi Wu
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Xingqi Wu
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Lei Zhang
- Department of Medical Psychology, Chaohu Clinical Medical College, Anhui Medical University, Hefei, China
- Lei Zhang
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Lei Zhang
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Fengqiong Yu
- Department of Medical Psychology, Chaohu Clinical Medical College, Anhui Medical University, Hefei, China
- Fengqiong Yu
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Fengqiong Yu
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Tongjian Bai
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Tongjian Bai
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Tongjian Bai
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Chunyan Zhu
- Department of Medical Psychology, Chaohu Clinical Medical College, Anhui Medical University, Hefei, China
- Chunyan Zhu
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Chunyan Zhu
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Yanghua Tian
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Yanghua Tian
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Yanghua Tian
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Kai Wang
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Kai Wang
- Department of Medical Psychology, Chaohu Clinical Medical College, Anhui Medical University, Hefei, China
- Kai Wang
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Kai Wang
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- DOI
- https://doi.org/10.3389/fnins.2020.00237
- Journal volume & issue
-
Vol. 14
Abstract
To understand the neural mechanism of repetitive transcranial magnetic stimulation (rTMS), the after-effects following one session or multiple days of stimulation have been widely investigated. However, the relation between the short-term effect (STE) and long-term effect (LTE) of rTMS is largely unknown. This study aims to explore whether the after-effects of 5-day rTMS on supplementary motor area (SMA) network could be predicted by one-session response. A primary cohort of 38 healthy participants underwent five daily sessions of real or sham continuous theta-burst stimulation (cTBS) on the left SMA. Resting-state functional magnetic resonance imaging (fMRI) data were acquired at the first (before and after the first stimulation) and sixth experimental day. The SMA connectivity changes after the first cTBS and after 5 days of stimulation were defined as STE and LTE, respectively. Compared to the baseline, significant STE and LTE were found in the bilateral paracentral gyrus (ParaCG) after real stimulation, suggesting shared neural correlates of short- and long-term stimulations. Region-of-interest analysis indicated that the resting-state functional connectivity between SMA and ParaCG increased after real stimulation, while no significant change was found after sham stimulation. Leave-one-out cross-validation indicated that the LTE in ParaCG could be predicted by the STE after real but not sham stimulations. In an independent cohort, the after-effects of rTMS on ParaCG and short- to long-term prediction were reproduced at the region-of-interest level. These imaging evidences indicate that one-session rTMS can aid to predict the regions responsive to long-term stimulation and the individualized response degree.
Keywords
- continuous theta-burst stimulation
- functional connectivity
- magnetic resonance imaging
- transcranial magnetic stimulation
- supplementary motor area
