Case report: SARS-CoV-2 specific T-cells are associated with myocarditis after COVID-19 vaccination with mRNA-1273

Ulrik Stervbo; Marc Van Bracht; Stathis Philippou; Nina Babel; Nina Babel; Timm H. Westhoff

doi:10.3389/fmed.2023.1088764

Frontiers in Medicine (Mar 2023)

Case report: SARS-CoV-2 specific T-cells are associated with myocarditis after COVID-19 vaccination with mRNA-1273

Ulrik Stervbo,
Marc Van Bracht,
Stathis Philippou,
Nina Babel,
Nina Babel,
Timm H. Westhoff

Affiliations

Ulrik Stervbo: Medical Department I, Center for Translational Medicine and Immune Diagnostics Laboratory, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Herne, Germany
Marc Van Bracht: Department of Cardiology, Augusta-Krankenanstalt Bochum, Bochum, Germany
Stathis Philippou: Augusta-Krankenanstalt Bochum, Institute for Pathology and Cytology, Bochum, Germany
Nina Babel: Medical Department I, Center for Translational Medicine and Immune Diagnostics Laboratory, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Herne, Germany
Nina Babel: Corporate Member of Freie Universität Berlin, Berlin Center for Advanced Therapies, Charité–Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany
Timm H. Westhoff: Medical Department I, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Herne, Germany

DOI: https://doi.org/10.3389/fmed.2023.1088764
Journal volume & issue: Vol. 10

Abstract

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Vaccination of SARS-CoV-2 with BNT162b2 or mRNA-1273 both have a low incidence of induction of myocarditis. Here we report on utilizing adaptive immune receptor repertoire sequencing (AIRR-Seq) as a way to assess the specificity of tissue infiltrating immune cells.

Published in Frontiers in Medicine

ISSN: 2296-858X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.frontiersin.org/journals/medicine

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