Frontiers in Immunology (Dec 2024)

Interaction between ischemia-reperfusion injury and intestinal microecology in organ transplantation and its therapeutic prospects

  • Yong-qi Lian,
  • Peng-fei Li,
  • Yan Guo,
  • Yan-lin Tao,
  • Ya-nan Liu,
  • Zhao-yu Liang,
  • Shu-fen Zhu

DOI
https://doi.org/10.3389/fimmu.2024.1495394
Journal volume & issue
Vol. 15

Abstract

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Organ transplantation is a vital intervention for end-stage organ failure; however, ischemia-reperfusion injury is a complication of transplantation, affecting the prognosis and survival of transplant recipients. As a complex ecosystem, recent research has highlighted the role of the intestinal microecology in transplantation, revealing its significant interplay with ischemia-reperfusion injury. This review explores the interaction between ischemia-reperfusion injury and intestinal microecology, with a special focus on how ischemia-reperfusion injury affects intestinal microecology and how these microecological changes contribute to complications after organ transplantation, such as infection and rejection. Based on a comprehensive analysis of current research advances, this study proposes potential strategies to improve transplant outcomes, offering guidance for future research and clinical practice.

Keywords