NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance

Karthigayan Shanmugasundaram; Bijaya K. Nayak; William E. Friedrichs; Dharam Kaushik; Ronald Rodriguez; Karen Block

doi:10.1038/s41467-017-01106-1

Nature Communications (Oct 2017)

NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance

Karthigayan Shanmugasundaram,
Bijaya K. Nayak,
William E. Friedrichs,
Dharam Kaushik,
Ronald Rodriguez,
Karen Block

Affiliations

Karthigayan Shanmugasundaram: Department of Medicine, UT Health
Bijaya K. Nayak: Department of Medicine, UT Health
William E. Friedrichs: Department of Medicine, UT Health
Dharam Kaushik: Department of Urology, UT Health
Ronald Rodriguez: Department of Urology, UT Health
Karen Block: Department of Medicine, UT Health

DOI: https://doi.org/10.1038/s41467-017-01106-1
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

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NADPH oxidase NOX4 has been linked to poor cancer survival. Here the authors show that NOX4 regulates drug resistance in renal cancer carcinoma by regulating PKM2 and that NOX4 activity is allosterically activated by reduced mitochondrial ATP levels thus coupling energy metabolism to drug resistance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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