Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system

S. Yamanaka; S. Tajiri; T. Fujimoto; K. Matsumoto; S. Fukunaga; B. S. Kim; H. J. Okano; T. Yokoo

doi:10.1038/s41467-017-01922-5

Nature Communications (Nov 2017)

Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system

S. Yamanaka,
S. Tajiri,
T. Fujimoto,
K. Matsumoto,
S. Fukunaga,
B. S. Kim,
H. J. Okano,
T. Yokoo

Affiliations

S. Yamanaka: Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine
S. Tajiri: Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine
T. Fujimoto: Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine
K. Matsumoto: Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine
S. Fukunaga: Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine
B. S. Kim: Division of Regenerative Medicine, Jikei University School of Medicine
H. J. Okano: Division of Regenerative Medicine, Jikei University School of Medicine
T. Yokoo: Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine

DOI: https://doi.org/10.1038/s41467-017-01922-5
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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The transplantation of tissue-specific progenitor cells may be an approach in organ regeneration. Here the authors show that the nephron progenitor population of a developing mouse kidney, when ablated, can be replaced by exogenously supplied rat nephron progenitors, generating interspecies nephrons.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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