6β-Chloro-5α-hydroxy-20-oxopregnan-3β-yl acetate

Abstract

The title steroid, C23H35ClO4, is a pregnane derivative prepared by ring opening of the corresponding 5α,6α-epoxy steroid with BiCl3. There are two symmetry-independent molecules in the asymmetric unit that show no significant differences concerning bond lengths and angles. The conformation of the six-membered rings in both molecules is close to a chair form, while the five-membered ring adopts an envelope conformation. All rings in both molecules are trans-fused. The molecules are held together by an extensive O—H...O hydrogen-bonding network.