Effect of antihistamine-releasing contact lenses on ocular symptoms and treatment behavior in patients with seasonal allergic conjunctivitis: A retrospective study

Kenta Fujio; Jaemyoung Sung; Kunihiko Hirosawa; Masahiro Yamaguchi; Hiroshi Toshida; Keiji Inagaki; Gaku Ishida; Motozumi Itoi; Kazushige Sado; Hiroo Hayatsu; Hirayama Nobutaka; Junji Ono; Hidetaka Taniguchi; Masao Iwagami; Ken Nagino; Yuichi Okumura; Akie Midorikawa-Inomata; Yasutsugu Akasaki; Tianxiang Huang; Yuki Morooka; Tomoko Okuyama; Shintaro Nakao; Akira Murakami; Hiroyuki Kobayashi; Takenori Inomata

Heliyon (Jul 2024)

Effect of antihistamine-releasing contact lenses on ocular symptoms and treatment behavior in patients with seasonal allergic conjunctivitis: A retrospective study

Kenta Fujio,
Jaemyoung Sung,
Kunihiko Hirosawa,
Masahiro Yamaguchi,
Hiroshi Toshida,
Keiji Inagaki,
Gaku Ishida,
Motozumi Itoi,
Kazushige Sado,
Hiroo Hayatsu,
Hirayama Nobutaka,
Junji Ono,
Hidetaka Taniguchi,
Masao Iwagami,
Ken Nagino,
Yuichi Okumura,
Akie Midorikawa-Inomata,
Yasutsugu Akasaki,
Tianxiang Huang,
Yuki Morooka,
Tomoko Okuyama,
Shintaro Nakao,
Akira Murakami,
Hiroyuki Kobayashi,
Takenori Inomata

Affiliations

Kenta Fujio: Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
Jaemyoung Sung: Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Ophthalmology, Tulane University School of Medicine, 131 S. Robertson St., 12th Floor, New Orleans, LA, 70112, USA
Kunihiko Hirosawa: Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
Masahiro Yamaguchi: Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
Hiroshi Toshida: Department of Ophthalmology, Shizuoka Hospital, Juntendo University, Shizuoka, Japan
Keiji Inagaki: Inagaki Eye Clinic, Chiba, Japan
Gaku Ishida: Ishida Eye Clinic, Nigata, Japan
Motozumi Itoi: Dogenzaka Itoi Eye Clinic, Tokyo, Japan
Kazushige Sado: Kamaishi Bay Eye Clinic, Iwate, Japan
Hiroo Hayatsu: Hayatsu Eye Clinic, Tochigi, Japan
Hirayama Nobutaka: Hirayama Eye Clinic, Tokyo, Japan
Junji Ono: Ono Eye Clinic, Shizuoka, Japan
Hidetaka Taniguchi: Okachimachi Taniguchi Eye Clinic, Tokyo, Japan; Shinshizuoka Taniguchi Eye Clinic, Shizuoka, Japan
Masao Iwagami: Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
Ken Nagino: Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Telemedicine and Mobile Health, Juntendo University Graduate School of Medicine, Tokyo, Japan
Yuichi Okumura: Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Telemedicine and Mobile Health, Juntendo University Graduate School of Medicine, Tokyo, Japan
Akie Midorikawa-Inomata: Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Telemedicine and Mobile Health, Juntendo University Graduate School of Medicine, Tokyo, Japan
Yasutsugu Akasaki: Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
Tianxiang Huang: Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
Yuki Morooka: Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
Tomoko Okuyama: Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
Shintaro Nakao: Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
Akira Murakami: Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
Hiroyuki Kobayashi: Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan
Takenori Inomata: Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Telemedicine and Mobile Health, Juntendo University Graduate School of Medicine, Tokyo, Japan; Corresponding author. Department of Ophthalmology, Juntendo University Graduate School of Medicine 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Journal volume & issue: Vol. 10, no. 13
p. e33385

Abstract

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Purpose: This study aimed to compare subjective allergic conjunctivitis symptoms and anti-allergic eye drop use patterns between antihistamine-releasing contact lens users and daily disposable soft contact lens users during Japan's hay fever season. Methods: This web-based retrospective cohort study included daily disposable soft contact lens or antihistamine-releasing contact lens users with a history of seasonal allergic conjunctivitis who regularly used daily disposable soft contact lenses since the previous year. The total ocular symptom score (range 0–20) based on 5-item questionnaire scores and time from the start of the hay fever season to the initiation of anti-allergic eye drop treatment were compared between antihistamine-releasing contact lens users and daily disposable soft contact lens users. Results: The study included 24 participants: 17 using daily disposable soft contact lenses and 7 using antihistamine-releasing contact lenses. Antihistamine-releasing contact lens users experienced a greater reduction in total ocular symptom score from 2021 to 2022 compared with daily disposable soft contact lens users (mean total ocular symptom score [standard deviation]: daily disposable soft contact lens: −0.65 [1.4], antihistamine-releasing contact lens: −4.7 [3.6]; n = 24; Mann–Whitney U test, P = 0.010). Fourteen daily disposable soft contact lens users and five antihistamine-releasing contact lens users eventually required anti-allergic eye drops. Kaplan–Meier analysis revealed a significant delay in the initiation of anti-allergic eye drop treatment among those using antihistamine-releasing contact lenses compared with those using daily disposable soft contact lenses (median days, daily disposable soft contact lenses: 19 days, antihistamine-releasing contact lens: 57 days; n = 24; log-rank test, P = 0.045). Conclusions: Antihistamine-releasing contact lenses can potentially mitigate worsening ocular allergic responses during the hay fever season when used appropriately as a preventive measure.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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